I take one of these PPI drugs.  Will I ever be able to get off it?

It depends on what disorder you are treating with the drug.  A full discussion of each and every condition for which PPI's are used is well beyond the scope of this Q & A.  Some disorders only require treatment for a month or two.  However, if you have gastroesophageal reflux disease (GERD), there are a number of anatomical features and physiologic abnormalities of your stomach and esophagus which promote reflux; these derangements of anatomy and physiology will always be present for the rest of your life and require acid lowering treatment to protect your esophagus.  The stomach is designed to be a vessel which contains Hydrochloric acid, a very strong acid.  The lining of the esophagus is made from a different type of tissue which is not acid resistant.  The esophagus was never designed to be a container for acid, and when acid enters the esophagus, it damages the lining of the esophagus.  Some people can keep the acid out of their esophagus 24/7 by sleeping on a slanted bed, staying upright for 2-3 hours after eating, losing weight, and completely avoiding aspirin, alcohol, caffeine, chocolate, peppermint, and nicotine.  These people can get away with not taking acid lowering drugs because they keep their stomach acid down in the stomach where it belongs 24/7.  In the absence of being able to follow such measures and  control reflux completely with these lifestyle modifications, it will be necessary to take a PPI for the rest of your life.  There are a number of studies which show that if physicians stop PPI's in people who have the anatomic or physiological conditions which facilitate reflux, symptoms of heartburn or fluid coming up into the chest or throat gradually return each week in more of these patients until almost everyone has experienced a full recurrence of their problems.  The exceptions to this rule are few and notable.